Associations of maternal hypertensive disorders during pregnancy with offspring risks of ischemic heart disease and stroke: a Nordic cohort study

Abstract Background A substantial body of evidence suggests that children exposed to maternal hypertensive disorders during pregnancy (HDP) have increased risks preterm birth, fetal growth restriction and several cardiovascular risk factors (e.g., hypertension, obesity, diabetes) later in life. However, the direct on link between HDP severe diseases such as ischemic heart disease (IHD) stroke offspring is very limited. Objective To investigate associations IHD offspring. Methods We conducted a population-based cohort study by linking national registers Sweden Finland. Live singleton births from Swedish Medical Birth Register (1973–2014) Finnish (1987- 2014) were followed for until 2014 patient cause death registers. performed Cox regression models examine association its subtypes, i.e., pre-existing chronic gestational preeclampsia, IHD, while adjusting relevant pregnancy-related confounders. sibling analyses control unmeasured shared familial (genetic and/or environmental) factors. Results Among 5,807,122 singletons included study, 218,322 (3.76%) born mothers with HDP. During up 41 years follow-up, 2,340 (0.04%) diagnosed 5,360 (0.09%) stroke. Offspring had an (adjusted hazard ratio (aHR), 1.29; 95% confidence interval (CI), 1.01–1.63), (aHR,1.33; CI, 1.14–1.56). Significantly rates also observed subtypes HDP: hypertension (aHR, 1.64; 1.03–2.60), (HR, 1.38; 1.08–1.77), preeclampsia 1.26; 1.02–1.55). The offspring's independent birth small age at birth. Maternal remained associated 1.94; 1.16–3.22), but not 0.89; 0.47–1.67) analyses. Conclusion Children childhood young adulthood. While seemed be attributed confounding factors, relation persisted even when considering confounding. Persons may benefit early screening prevention efforts reduce FUNDunding Acknowledgement Type funding sources: Foundation. Main source(s): Heart Lung Foundation